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Some agents teratogenic to the chick embryo cause serum electrolyte and fluid imbalances which initiate an edema syndrome leading to malformations. Differences in ionic composition of serum and yolk of normal chicks help explain how these imbalances can be produced. A study of the effects of moderate hypoxia on young chick embryos, has shown that many of the induced malformations can be attributed to a disturbance in fluid balance (1). This disturbance, which characterizes the edema syndrome,doi:10.1126/science.142.3595.1064 pmid:14068221 fatcat:gwg5ex73wzezlo2vxryfro7tm4