Teratogenic Significance of Ionic and Fluid Imbalances

C. T. Grabowski
1963 Science  
Some agents teratogenic to the chick embryo cause serum electrolyte and fluid imbalances which initiate an edema syndrome leading to malformations. Differences in ionic composition of serum and yolk of normal chicks help explain how these imbalances can be produced. A study of the effects of moderate hypoxia on young chick embryos, has shown that many of the induced malformations can be attributed to a disturbance in fluid balance (1). This disturbance, which characterizes the edema syndrome,
more » ... e edema syndrome, includes a marked increase in circulating and extracellular fluids, followed by the formation of clear blisters and hematomas which cause malformations mechanically. The edema syndrome can also be induced by Trypan blue (2) and injections of Abstract. Some agents teratogenic to the chick embryo cause serum electrolyte and fluid imbalances which initiate an edema syndrome leading to malformations. Differences in ionic composition of serum and yolk of normal chicks help explain how these imbalances can be produced. A study of the effects of moderate hypoxia on young chick embryos, has shown that many of the induced malformations can be attributed to a disturbance in fluid balance (1). This disturbance, which characterizes the edema syndrome, includes a marked increase in circulating and extracellular fluids, followed by the formation of clear blisters and hematomas which cause malformations mechanically. The edema syndrome can also be induced by Trypan blue (2) and injections of as in genetic mutants (9; 10).
doi:10.1126/science.142.3595.1064 pmid:14068221 fatcat:gwg5ex73wzezlo2vxryfro7tm4