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EFFECTS OF ANDROGENIC HORMONES ON THE EXPRESSION OF ISOZYMES OF LACTATE DEHYDROGENASE IN THE MASSETER MUSCLE AND TONGUE OF MICE
Daily subcutaneous injections of 50:-androstane-3a,17,8-diol (50:-A-diol), testosterone or combination of both hormones into testectomized mice caused an increase in the muscletype LDH (LDH 5) activity reduced by testectomy, and induced the precocious appearance of the adult male-type distribution of LDH isozymes in developing mice. In adult mice, testectomy reduced the ratio of LDH 5 in the masseter muscle to the female level. Cyproterone acetate depressed the appearance of the male-typedoi:10.2220/biomedres.14.233 fatcat:hly4g7thlncgbmuqbmyhvl63va