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20-Hydroxyeicosatetraenoic Acid Mediates Isolated Heart Ischemia/Reperfusion Injury by Increasing NADPH Oxidase-Derived Reactive Oxygen Species Production
2013
Circulation Journal
It has been reported that 20-hydroxyeicosatetraenoic acid (20-HETE) aggravates myocardial ischemia/reperfusion (I/R) injury, but the exact mechanism of action is still unclear. Methods and Results : Experiments were performed in isolated rat hearts subjected to 35 min of ischemia followed by 40 min of reperfusion in Langendorff preparations. Perfusion with HET0016, an inhibitor of 20-HETE production, significantly improved I/R-induced reduction in cardiac contractility, myocardial infarction,
doi:10.1253/circj.cj-12-1211
pmid:23585488
fatcat:xqdyhfnkpfa2jdmywxvb34fvje