Effects of Shift-Work on the Carotid Artery and Cerebral Blood Flow of SHR Rats and WKY Rats [article]

Yunlei Wang, Tong Zhang, Yuge Zhang, Yan Yu, Fan Bai, Haojie Zhang, Yafei Chi, Shan Gao
2019 bioRxiv   pre-print
Objective: The objective was to investigate the effects of shift-work (SW) on the carotid arteries. Methods: This study used two inverted photoperiods (inverted light:dark [ILD]16:8 and ILD12:12) to create the SW model. We recorded the rhythm and performed serological tests, carotid ultrasound, magnetic resonance imaging, and carotid biopsy. Results: SW induced elevated blood pressure and increased angiotensin-II, apolipoprotein E, blood glucose, and triglycerides. SW increased the carotid
more » ... a-media thickness. SW led to the development of carotid arterial thrombosis, reduced cerebral blood flow, and increased the number of collagen fibers, expression of angiotensin receptor and low-density lipoprotein receptor in the carotid arteries. SW decreased 3-hydroxy-3-methylglutaryl-CoA reductase and nitric oxide. SW induced the atherosclerotic plaque in the aorta. Multiple results of SHR were worse than WKY rats. Conclusion: SW can induce metabolic disorders and elevated blood pressure. SW can cause intima-media thickening of the carotid artery and aorta atherosclerosis. SW may result in carotid arterial thrombosis and affect cerebral blood flow. Hypertension can aggravate the adverse effects of SW. Keywords: shift-work, hypertension, metabolic disorders, thrombosis, atherosclerosis
doi:10.1101/740068 fatcat:3ihwo6r6inbk7ml7utaa3wbdj4