Acute hemodynamic effects of captopril in children with a congestive or restrictive cardiomyopathy

A R Bengur, R H Beekman, A P Rocchini, D C Crowley, M A Schork, A Rosenthal
1991 Circulation  
The acute hemodynamic effects of captopril were evaluated at cardiac catheterization in 16 children (age, 0.3-18 years) with cardiomyopathy. Twelve children had congestive cardiomyopathy, whereas four had restrictive cardiomyopathy. Hemodynamic measurements were obtained 30 and 60 minutes after the oral administration of captopril (0.5 mg/kg). Blood pressures were measured in the aorta, pulmonary artery, right atrium, and pulmonary capillary wedge position; cardiac outputs were measured by the
more » ... re measured by the thermodilution technique. Hemodynamic data could not be obtained after the administration of captopril in one child with congestive cardiomyopathy because of an immediate, severe hypotensive response. In 11 of 12 children with congestive cardiomyopathy, cardiac index increased by 22%, from 2.3 to 2.8 1/min/m2 (p<0.05), and stroke volume increased by 22%, from 23 to 28 mI/m2 (p<0.05).
doi:10.1161/01.cir.83.2.523 pmid:1991370 fatcat:ci2s3d7oarbtne24yw6nh5bhjq