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F1000 - Post-publication peer review of the biomedical literature
During vertebrate mitosis, the centromere-associated kinesin CENP-E transports misaligned chromosomes to the plus ends of spindle microtubules. Subsequently, the kinetochores that form at the centromeres establish stable associations with microtubule ends, which assemble and disassemble dynamically. Here we provide evidence that after chromosomes have congressed and bi-oriented, the CENP-E motor continues to play an active role at kinetochores, enhancing their links with dynamic microtubuledoi:10.3410/f.718077576.793483612 fatcat:zqmub4ijobat3ac7yq6vcvvxiq