Recent medical engineering made remarkable progress in the field of blood purification, too. The technological advance lead to expansion of indicative disease, for example we have been perfoming the therapeutic procedure to not only renal failure, but also hepatic failure, auto-immune disease, and hyperlipidemia. These advances brought marked improvement of filtration function of membrane for blood purification. Various sized-molecular substances, which may be pathognomonic in disease, may be

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... ducible in some degree. The more sharpe molecular cut-off point of the membrane becomes. the more successful effectiveness blood purification exerts. Furthermore, the membrane, which is superior in biocompatibility, has been requested. Such requirement is stressed especially in uremic patients who have to undergo maintenance hemodialysis. The paper will discuss about removal rate of uremic toxins and biocompatibility in the uremic patients.