A Discussion on Recently Introduced Hypnotics and Analgesics
BMJ (Clinical Research Edition)
this account that chloral hydral (CC13 CH (1H)2), though an admirable hypnotic, may give rise to evils which are not produced by the newer and non-chlorinated hypnotics. By combining chloral with other groups, it has been sought in some degree to minimise these possible evils, and the two last substances in the list have been introduced with this view. Apart from chemical structure, the physical properties of compounds influence their physiological effects; hence it is that some ok the
... ome ok the combinations into which alcoholic radicles enter are anvethetic, some hypnotic; antesthetics being found amongst those substances which are volatile and quickly eliminated, soporifics amongst those which have a heavy molecule and are either liquid or soluble in form, so that they may be given by the mouth, and, being absorbed into the blood, may continue to act.2 As the action and utility of hypnotic agents are greatly affected by their physical characteristics, I will shortly set forth the points of chief importance relating to them. Urethane is a solid, very soluble in water, without much taste, and without unpleasant smell, though some specimens have a foul, mouselike odour, due probably to acetamide, produced during the manufacture of the drug.3 It was introduced by Schmiedeberg in 1885.4 Aeetal is a light-coloured fluid with an unpleasant smell and taste, which was proved by von Mering5 to have soporific properties in doses of one to three drachms. Methylal is a motile, colourless fluid, with a chloroform-like smell and pungent,; slightly bitter taste. When impure, as Dr. THE BRIIS MEIA JUNL can be little doubt that the chlorinated compound exerts its influence with greater certainty than, either of the other two, whilst, 15 Deutsche med.