Phosphorylated Caveolin-1 Regulates Rho/ROCK-Dependent Focal Adhesion Dynamics and Tumor Cell Migration and Invasion

B. Joshi, S. S. Strugnell, J. G. Goetz, L. D. Kojic, M. E. Cox, O. L. Griffith, S. K. Chan, S. J. Jones, S.-P. Leung, H. Masoudi, S. Leung, S. M. Wiseman (+1 others)
2008 Cancer Research  
Rho/ROCK signaling and caveolin-1 (Cav1) are implicated in tumor cell migration and metastasis; however, the underlying molecular mechanisms remain poorly defined. Cav1 was found here to be an independent predictor of decreased survival in breast and rectal cancer and significantly associated with the presence of distant metastasis for colon cancer patients. Rho/ROCK signaling promotes tumor cell migration by regulating focal adhesion (FA) dynamics through tyrosine (Y14
doi:10.1158/0008-5472.can-08-0343 pmid:18922892 fatcat:h3n36upkm5enll3nrkz66rh3by