Progressive Diffuse Pulmonary Interstitial Opacities due to Complications of Pulmonary Tumor Emboli: An Autopsy Case Report

Yutaka Yoshii, Yoshinori Kawabata, Noboru Takayanagi, Jun Araya, Kazuyoshi Kuwano, Yutaka Sugita
2015 Internal medicine (Tokyo. 1992)  
A 76-year-old man complaining of exertional dyspnea was admitted to our hospital. Chest computed tomography revealed bilateral diffuse ground-glass opacities and small nodules. A transbronchial lung biopsy revealed tumor cell emboli in the pulmonary arteries. The patient was diagnosed with gastric adenocarcinoma using an endoscopic stomach biopsy; however, the interstitial opacities progressively worsened and he died of acute respiratory failure. An autopsy revealed extensive pulmonary tumor
more » ... pulmonary tumor embolisms (PTE) with associated ischemic damages, e.g., infarctions, alveolar wall thickening with cuboidal metaplasia, hemorrhage, and diffuse alveolar damage. The ground-glass opacities in the chest computed tomography findings appear to correlate with the pathological ischemic changes associated with PTE.
doi:10.2169/internalmedicine.54.3476 pmid:25876580 fatcat:5spjecvvbrfthn5ebjt3wh3hla