In Vitro Activities of 11 Antimicrobial Agents against Macrolide-Resistant Mycoplasma pneumoniae Isolates from Pediatric Patients: Results from a Multicenter Surveillance Study

Hiroto Akaike, Naoyuki Miyashita, Mika Kubo, Yasuhiro Kawai, Takaaki Tanaka, Satoko Ogita, Kozo Kawasaki, Takashi Nakano, Kihei Terada, Kazunobu Ouchi, the Atypical Pathogen Study Group
2012 Japanese journal of infectious diseases (Print)  
Macrolide-resistant Mycoplasma pneumoniae is emerging in several countries, and it is mainly observed in children. To our knowledge, we conducted the first multicenter prospective epidemiological study of macrolide-resistant M. pneumoniae in order to investigate regional differences in the susceptibility of macrolide-resistant M. pneumoniae to antibacterial agents. The in vitro activities of 11 antimicrobial agents against macrolide-resistant M. pneumoniae isolates from 5 different areas of
more » ... n were investigated. Among 190 M. pneumoniae isolates from pediatric patients, 124 (65.2z) isolates showed macrolide resistance and possessed an A2063G transition in domain V of the 23S rRNA. These isolates showed high resistance to erythromycin, clarithromycin, and azithromycin with minimum inhibitory concentrations (MICs) AE16 mg/ml. Conversely, quinolones such as garenoxacin, moxifloxacin, tosufloxacin, and levofloxacin exhibited potent antimycoplasmal activity. No regional differences were observed with respect to the MICs among the 5 areas in Japan.
doi:10.7883/yoken.65.535 fatcat:u6s2mmlwgveyre2anjyeeh2xjq