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Cellular evaluation of insulin transmucosal delivery
Journal of Biomaterials Science. Polymer Edition
P(MAA-g-EG) microparticles have been extensively investigated as carriers for oral delivery of proteins such as insulin. In this study, we investigated the effect of the molecular weight of the PEG tethered chains in the copolymer network and of the microparticle size on the transepithelial electrical resistance (TEER) and insulin epithelial permeability, using monolayers of human intestinal epithelial Caco-2 cells. Two molecular weights of the PEG chains, 400 and 1000, were investigated, asdoi:10.1163/156856204323005262 pmid:15212324 fatcat:krcwoccf7veyxgsxvb5z7mwcku