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Short of a liver biopsy, hepatic disease and drug-induced liver injury are diagnosed and classified from clinical findings, especially laboratory results. It was hypothesized that a healthy hepatic dynamic equilibrium might be modelled by an Ornstein–Uhlenbeck (OU) stochastic process, which might lead to more sensitive and specific diagnostic criteria. Using pooled data from healthy volunteers in pharmaceutical clinical trials, this model was applied using maximum likelihood (ML) methods. Itdoi:10.1080/17486700802653925 fatcat:nujxjc2dfzgx7g4u6imcwwpmdm