Treatment of cutaneous lichen planus (Part 1): A review of topical therapies and phototherapy

Yasmeen Thandar, Rivesh Maharajh, Firoza Haffejee, Anisa Mosam, Udo Schumacher
2019 Cogent Medicine  
Lichen planus is a chronic inflammatory immune-mediated disease that more frequently affects the skin and oral mucosa. Various treatment modalities are available for the condition. The aim of this review is to provide clinicians with consolidated evidence of the various treatments of cutaneous lichen planus (CLP). This first part focuses on topical therapies and phototherapy. Methods: Various Databases were searched for all studies up until January 2018, which reported on topical therapies and
more » ... ical therapies and phototherapy for CLP. There were no exclusions based on study design. Results: We identified four systemic reviews and four reviews. We found additional single studies that contributed to this review. Evidence supporting the use of topical corticosteroids, as a first-line therapy, is absent. Conclusion: Narrowband UVB is the preferred phototherapeutic treatment option for cutaneous lichen planus and should be considered before commencing systemic treatment. Topical calcineurin inhibitors show promising results despite evidence only available from case reports. Vitamin D 3 is not recommended for the treatment of cutaneous lichen planus due to poor patient outcomes. The second part of this ABOUT THE AUTHORS Yasmeen Thandar is a senior pharmacology lecturer at Durban University of Technology (DUT) in South Africa. She is a clinical pharmacologist with a PhD in Pharmacology from University of KwaZulu-Natal (UKZN). Her research interests lie in the evidence-based role of treating diseases, particularly in inflammatory skin diseases. Rivesh Maharajh has a
doi:10.1080/2331205x.2019.1582467 fatcat:3qhmmputuzfadmr7ngweqj25xe