Combined Genome and Transcriptome Analysis of Single Disseminated Cancer Cells from Bone Marrow of Prostate Cancer Patients Reveals Unexpected Transcriptomes

M. Gu vi, B. Braun, R. Ganzer, M. Burger, M. Nerlich, S. Winkler, M. Werner-Klein, Z. T. Czyz, B. Polzer, C. A. Klein
2014 Cancer Research  
Bone is the most frequent site of metastasis in prostate cancer and patients with bone metastases are deemed incurable. Targeting prostate cancer cells that disseminated to the bone marrow before surgery and before metastatic outgrowth may therefore prevent lethal metastasis. This prompted us to directly analyze the transcriptome of disseminated cancer cells (DCC) isolated from patients with nonmetastatic (UICC stage M0) prostate cancer. We screened 105 bone marrow samples of patients with
more » ... age prostate cancer and 18 bone marrow samples of patients without malignancy for the presence of EpCAM þ single cells.
doi:10.1158/0008-5472.can-14-0934 pmid:25320011 fatcat:noacz35f6jbx5jocjyr3hl2gaa