Antihypertensive treatment prescription in pediatric dialysis patients in Poland: A comparison between two nationwide studies 2003/2004–2013

Krzysztof Wróblewski, Karolina Hincz, Monika Miklaszewska, Katarzyna Zachwieja, Ryszard Wierciński, Roman Stankiewicz, Agnieszka Firszt-Adamczyk, Jacek Zachwieja, Hanna Borzęcka, Helena Ziółkowska, Danuta Zwolińska, Marcin Tkaczyk
2017 Advances in Clinical and Experimental Medicine  
Background. Blood pressure in pediatric dialyzed patients is under poor control. Objectives. The aim of the study was to assess the strategy and efficacy of antihypertensive drugs used for the treatment of hypertension in pediatric dialyzed patients in 2013 in comparison with the data collected in 2003/2004. The results have been viewed against present strategies of antihypertensive treatment in children. There is still limited data concerning the treatment of hypertension in dialyzed pediatric
more » ... dialyzed pediatric patients. Material and methods. The study embraced 10 of 12 pediatric dialysis units in Poland treating 59 pediatric patients (mean age -132 months). Collected information included present antihypertensive treatment with regard to drug classes and the dose of antihypertensive agent. The treatment was regarded as effective if both systolic and diastolic values of blood pressure were below 1.64 SDS. The results from 2013 were juxtaposed with previously analyzed data from a similar study on hypertension in dialyzed children conducted in 2003/2004. Results. Forty subjects have been provided with antihypertensive treatment. In monotherapy and polytherapy 50% of the subjects were treated with ACEI (enalapril and ramipril), 67.5% with amlodipine, 50% with beta-blockers. Only 10% of the subjects were treated with angiotensin II receptor blocker (losartan). Thirty percent of the subjects received furosemide, whereas 5% were given doxazosin. Antihypertensive drugs regarded as the 2 nd and 3 rd choice in treating high blood pressure (doxazosin, beta-blockers and furosemide) were applied as monotherapy in 46% of the patients. Satisfactory control of treated blood pressure was reached in 45% of them. Original papers Antihypertensive treatment prescription in pediatric dialysis patients in Poland: A comparison between two nationwide studies
doi:10.17219/acem/65823 pmid:29264885 fatcat:kyufwlzzm5dorfj2ygr7vr66ku