Prior exposure to thymidine analogues and didanosine is associated with long-lasting alterations in adipose tissue distribution and cardiovascular risk factors

Marco Gelpi, Shoaib Afzal, Andreas Fuchs, Jens Lundgren, Andreas D. Knudsen, Ninna Drivsholm, Amanda Mocroft, Anne-Mette Lebech, Birgitte Lindegaard, Jørgen T. Kühl, Per E. Sigvardsen, Lars Køber (+3 others)
2018 AIDS (London)  
This study suggests a potentially irreversible and harmful association of thymidine analogs and ddI with VAT accumulation, which appears be involved in the increased risk of hypertension, hypercholesterolemia, and low high-density lipoprotein found in PLWH with prior exposure to thymidine analogs and/or ddI, even years after treatment discontinuation.
doi:10.1097/qad.0000000000002119 pmid:30585844 fatcat:fuakult7mrb37bc5ovrkcmhaoa