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Intracellular cAMP Sensor EPAC: Physiology, Pathophysiology, and Therapeutics Development
2018
Physiological Reviews
This review focuses on one family of the known cAMP receptors, the exchange proteins directly activated by cAMP (EPACs), also known as the cAMP-regulated guanine nucleotide exchange factors (cAMP-GEFs). Although EPAC proteins are fairly new additions to the growing list of cAMP effectors, and relatively "young" in the cAMP discovery timeline, the significance of an EPAC presence in different cell systems is extraordinary. The study of EPACs has considerably expanded the diversity and adaptive
doi:10.1152/physrev.00025.2017
pmid:29537337
pmcid:PMC6050347
fatcat:2l6gw7vkprehxnszxg2dqni7ze