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Fluorescent approaches for understanding interactions of ligands with G protein coupled receptors
2014
Biochimica et Biophysica Acta - Biomembranes
G protein coupled receptors are responsible for a wide variety of signaling responses in diverse cell types. Despite major advances in the determination of structures of this class of receptors, the underlying mechanisms by which binding of different types of ligands specifically elicits particular signaling responses remain unclear. The use of fluorescence spectroscopy can provide important information about the process of ligand binding and ligand dependent conformational changes in
doi:10.1016/j.bbamem.2013.09.005
pmid:24055822
pmcid:PMC3926105
fatcat:ihdcthsmmzgarh5jc7j3w5scsa