PathwayExplorer: web service for visualizing high-throughput expression data on biological pathways

B. Mlecnik, M. Scheideler, H. Hackl, J. Hartler, F. Sanchez-Cabo, Z. Trajanoski
2005 Nucleic Acids Research  
While generation of high-throughput expression data is becoming routine, the fast, easy, and systematic presentation and analysis of these data in a biological context is still an obstacle. To address this need, we have developed PathwayExplorer, which maps expression profiles of genes or proteins simultaneously onto major, currently available regulatory, metabolic and cellular pathways from KEGG, BioCarta and GenMAPP. PathwayExplorer is a platform-independent web server application with an
more » ... onal standalone Java application using a SOAP (simple object access protocol) interface. Mapped pathways are ranked for the easy selection of the pathway of interest, displaying all available genes of this pathway with their expression profiles in a selectable and intuitive color code. Pathway maps produced can be downloaded as PNG, JPG or as highresolution vector graphics SVG. The web service is freely available at https://pathwayexplorer.genome. tugraz.at; the standalone client can be downloaded at http://genome.tugraz.at.
doi:10.1093/nar/gki391 pmid:15980551 pmcid:PMC1160152 fatcat:pb34fnphzfckppcqxcgeok3zmu