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T cells limit accumulation of aggregate pathology following intrastriatal injection of α-synuclein fibrils
[article]
2020
bioRxiv
pre-print
α-Synuclein (α-syn) is the predominant protein in Lewy-body inclusions, which are pathological hallmarks of α- synucleinopathies, such as Parkinsons disease (PD) and multiple system atrophy (MSA). Other hallmarks include activation of microglia, elevation of pro-inflammatory cytokines, as well as the activation of T and B cells. These immune changes point towards a dysregulation of both the innate and the adaptive immune system. T cells have been shown to recognize epitopes derived from α-syn
doi:10.1101/2020.02.20.956599
fatcat:jmir2iituba25lerga243lzfbe