Evaluation of the fibulin 5 gene polymorphism as a factor related to the occurrence of pelvic organ prolapse

Marcus Vinicius Barbosa de Paula, Marcos Antônio de Farias Lira Júnior, Vivian Costa e Silva Crocco Monteiro, Ricardo Peres Souto, César Eduardo Fernandes, Emerson de Oliveira
2020 Revista da Associação Médica Brasileira  
SUMMARY OBJECTIVE Pelvic organ prolapse (POP) is a very frequent situation in our population that may lead to a significant decrease in patients' quality of life. Currently, we are looking for predictive factors for the development of POPs; thus, this study seeks to evaluate whether the Fibulin 5 polymorphism (FBLN5) is associated with the occurrence of POP. METHODS This is a cohort study with postmenopausal women who were divided into groups by POP stage: POP stages 0 and I (control group) and
more » ... (control group) and POP stages III and IV (case group). Subsequently, analyses of genetic polymorphisms of FBLN5 were performed using the Restriction Fragment Length Polymorphism (RFLP) technique. RESULTS A total of 292 women were included in the study. Pregnancy, parity and vaginal delivery in the patients, as well as in data described in the literature, were related to the occurrence of POP in the univariate analysis. However, after binary logistic regression, home birth and age remained independent risk factors for POP. We found no association between the FBLN5 polymorphism and the occurrence of POP (p = 0.371). CONCLUSION There was no association between the FBLN5 polymorphism and the occurrence of POP in Brazilian women.
doi:10.1590/1806-9282.66.5.680 pmid:32638975 fatcat:d72l5kqvxngitel4efzqlmhoyu