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Objective: to identify prevalence and factors associated with anxiety and depression in nursing professionals who work to cope with COVID-19 at a university hospital. Methods: a cross-sectional observational study using a sociodemographic questionnaire and Hospital Anxiety and Depression Scale, with 88 nursing professionals. Data were analyzed using absolute and relative frequency and Statistical Package for the Social Sciences. Results: there was prevalence of anxiety (48.9%) and depressiondoi:10.1590/0034-7167-2020-0434 pmid:32667576 fatcat:akszd2p6w5dbnacys57tn7irwa