Magnesium in critical illness: metabolism, assessment, and treatment [chapter]

J. Luis Noronha, George M. Matuschak
2009 Applied Physiology in Intensive Care Medicine  
The body normally contains 21-28 g Mg [13] . Approximately 53% of total Mg stores are in bone, 27% in muscle, 19% in soft tissues, 0.5% in erythrocytes, and 0.3% in serum [14] . The Mg in muscle, soft tissues, and erythrocytes is considered to be intracellular [1], and mostly bound to chelators such as adenosine triphosphate (ATP), adenosine diphosphate (ADP), proteins, RNA, DNA, and citrate [14] . Although only 5-10% of intracellular Mg is ionized, this fraction is essential for regulating
more » ... for regulating intracellular Mg homeostasis [15] (Fig. 1) . Traditionally, extracellular Mg in serum was considered to be 33% protein bound, 7% complexed to citrate, PO 4 2-, and HCO 3 - [16] , and 55% circulating in the diva-
doi:10.1007/978-3-642-01769-8_36 fatcat:3t6ak2wx3zc6rns5wk6glqkdeq