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Molecular Mechanism of the Inhibition of Estradiol-Induced Endometrial Epithelial Cell Proliferation by Clomiphene Citrate
2010
Endocrinology
We examined the molecular mechanisms of the antiestrogenic effects of clomiphene citrate (CC) in the endometrium using two types of cell lines, Ishikawa and EM-E6/E7/hTERT cells. CC or ICI182780 inhibited 17-estradiol (E2)-induced endometrial cell proliferation and transcriptional activation of the estrogen response element (ERE) gene. We directly visualized the ligand-estrogen receptor (ER)␣ interaction using green fluorescent protein (GFP)-tagged ER␣ in a single living cell. Whereas E2
doi:10.1210/en.2009-0721
pmid:19934375
fatcat:laahniytpvh5vltljlqiaamwpu