Pecularities of lipid peroxidation in conditions of acute respiratory distress syndrome and its correction

O. V. Oliynyk, S. O. Savchuk, D. B. Korobko
2015 Medical and Clinical Chemistry  
<p>The article considers insufflation of oxygen, xanthine derivative – salt 3-(8-brom-1,3-dymethyl-2,6-dioxo-2,3-<br />dihidro-1Н-purin-7(6Н)-il)propanoat (substance "KD-234") and reamberin efficiency on the parameters of lipid<br />peroxidation (LPO) in middle-steady and low-steady to hypoxia rats with hydrochloric acid-inducedacute respiratory<br />distress syndrome.<br />It was established, that during experimental acute respiratory distress syndromein tissue of liver thecontentof<br
more » ... ontentof<br />TBA-active metabolits, diene and triene conjugate statistically reliably increase, moreover in middle-steady to hypoxia<br />rats the value of TBA-active metabolits and diene conjugate in this condition substantially less, than in low-steady to<br />hypoxia rats. The use with corrective purpose of oxygen insufflation promotеs to substantial decreasing of TBA-active<br />metabolits concentration in both experimental groups, moreover in middle-steady to hypoxia rats the rate become<br />reliably substantially less, than in low-steady to hypoxia rats. The useof xanthine derivative – substance "KD-234"<br />and reamberinis accompanied by similar deviations in content of TBA-active metabolitsin hepar tissue.</p>
doi:10.11603/mcch.2410-681x.2015.v17.i3.5051 fatcat:akew573qkzagddyxgd2zirnxfm