Renal Transplantation and Pregnancy
Sri Lanka Journal of Obstetrics and Gynaecology
Objective: The aim of this study is to evaluate maternal & fetal outcome in cases of renal transplant patients. Methods: This is a retrospective study from 2010 to 2012 at a tertiary care centre. We analyzed six pregnancies in five renal transplant recipients for maternal and fetal outcome in terms of clinical and biological data. Results: The mean age was 28.6 ± 3 years. The mean time interval between renal transplantation and pregnancy was 2 year & 7months. Regarding the immunosuppressive
... munosuppressive therapy all patients received steroids, three patients received Tacrolimus, one patient received Sirolimus and Mycophenolate Mofetil that was changed 1 month before conception. There was no significant difference between the serum creatinine levels before and during pregnancy. Amongst the five patients, two of them had pre -existing hypertension. Of these two patients, one developed super imposed pre-eclampsia. The other complications which were noted were urinary tract infection in one case, premature labour pain in one case, anaemia in two cases. No neonatal complication except low birth weight was noted. Two cases had spontaneous abortion. Caesarean section was performed in two cases due to severe oligohydroaminos. Conclusion: Pregnancy in renal transplant patient can be continued under optimal circumstances, including stable allograft function for at least 1 year post transplant without rejection with good control of blood pressure, and after appropriate adjustment of immunosuppressant and other known teratogenic medications prior to conception.