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H19 acts as a trans regulator of the imprinted gene network controlling growth in mice
The imprinted H19 gene produces a non-coding RNA of unknown function. Mice lacking H19 show an overgrowth phenotype, due to a cis effect of the H19 locus on the adjacent Igf2 gene. To explore the function of the RNA itself, we produced transgenic mice overexpressing H19. We observed postnatal growth reduction in two independent transgenic lines and detected a decrease of Igf2 expression in embryos. An extensive analysis of several other genes from the newly described imprinted gene networkdoi:10.1242/dev.036061 pmid:19762426 fatcat:mqcx4zly35gpjk2m6e7wlbtgyy