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C3 is the central component of the complement system and activation of C3 via any of the three major activation pathways-the classical, the lectin and the alternative pathways-results in initiation of the terminal complement pathway and release of the anaphylatoxin C3a. Both terminal pathway activation and signalling of C3a and its inactivation product C3a-desarg via the C3a receptor and C5a-like receptor 2, respectively, can induce inflammatory, immunomodulatory and metabolic responses. C3 hasdoi:10.1007/s00125-012-2462-z pmid:22282163 pmcid:PMC3295998 fatcat:cwbbk2nwsjan7lujyjmn5giud4