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Edited by B. Honig Keywords: protein structures; molecular interactions; protein-protein interactions; drug development hotspots The modulation of protein-protein interactions (PPIs) by small drug-like molecules is a relatively new area of research and has opened up new opportunities in drug discovery. However, the progress made in this area is limited to a handful of known cases of small molecules that target specific diseases. With the increasing availability of protein structure complexes,doi:10.1016/j.jmb.2011.12.026 pmid:22198293 pmcid:PMC3433052 fatcat:fofx6a7zgreprbztv3epdl6dvy