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ABSTRACTInitiation and progression of cancers is underpinned by somatic evolution, which follows Darwinian logic, i.e., diversification of heritable phenotypes provides a substrate for natural selection, resulting in the outgrowth of the most fit subpopulations. Whereas somatic evolution can tap into multiple sources of diversification, it is assumed to lack access to (para)sexual recombination - one of the most powerful diversification mechanisms throughout all strata of life. Based ondoi:10.1101/2020.03.09.984419 fatcat:krrlzp7cirh6fbgnvbrjnk27iy