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This study objective was to evaluate the cytokines associated with early events of hepatic fibrosis in schistosomiasis mansoni. Hepatic fibrosis was classified by ultrasonography in 94 patients. Immunological evaluation was performed by measurement of secreted cytokines (interleukin IL-5, IL-10, IL-13, interferon-γ, tumor necrosis factorα and transforming growth factors-β) in peripherl blood mononuclear cells stimulated by Schistosoma mansoni antigens. Significantly, higher levels of IL-5,doi:10.1590/s0074-02762004000900004 fatcat:nno2ncgrcvbadkgjlez2smvoiu