A rare case of humoral hypercalcemia of malignancy resulting from urothelial carcinoma

Jonathan Slusser, Brian Beluch, Alan J Shienbaum
2017 Cancer Reports and Reviews  
Humoral Hypercalcemia of malignancy is a common cause of hypercalcemia. This is typically associated with cancers of the head and neck and lung cancer. Case presentation: We describe a 75-year-old male with history of urothelial carcinoma since 2010 who presented with lethargy and acutely worsening weakness. His physical exam was unremarkable except for noted lethargy. Laboratory studies demonstrated elevated serum calcium with elevated serum PTHrP level. The patient's hypercalcemia responded
more » ... alcemia responded to bisphosphonate therapy. Tissue from the prior transurethral resection of his bladder tumor demonstrated evidence of neuroendocrine differentiation by immunohistochemistry. Conclusions: This represents a rare case of humoral hypercalcemia of malignancy resulting from recurrent urothelial carcinoma. Urothelial carcinoma is an uncommon cause of humoral hypercalcemia of malignancy and should be considered in the differential diagnosis of hypercalcemia in patients with a history of urothelial carcinoma or those at risk for this disease. Slusser J (2017) A rare case of humoral hypercalcemia of malignancy resulting from urothelial carcinoma
doi:10.15761/crr.1000115 fatcat:wmhi4cgcrvbavoqgowqru6a34a