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Transcatheter Mitral Repair for Functional Mitral Regurgitation According to Left Ventricular Function: A Real-Life Propensity-Score Matched Study

Isaac Pascual, Fernando Carrasco-Chinchilla, Tomas Benito-Gonzalez, Chi Hion Li, Pablo Avanzas, Luis Nombela-Franco, Manuel Pan, Ana Serrador Frutos, Xavier Freixa, Ramiro Trillo-Nouche, Rosa A. Hernández-Antolín, Leire Andraka Ikazuriaga (+39 others)
2020 Journal of Clinical Medicine  

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Transcatheter mitral valve repair (TMVR) could improve survival in functional mitral regurgitation (FMR), but it is necessary to consider the influence of left ventricular ejection fraction (LVEF). Therefore, we compare the outcomes after TMVR with Mitraclip® between two groups according to LVEF. Methods: In an observational registry study, we compared the outcomes in patients with FMR who underwent TMVR with and without LVEF <30%. The primary endpoint was the combined one-year all-cause
more » ... ty and unplanned hospital readmissions due to HF. The secondary end-points were New York Heart Association (NYHA) functional class and mitral regurgitation (MR) severity. Propensity-score matching was used to create two groups with the same baseline characteristics, except for baseline LVEF. Results: Among 535 FMR eligible patients, 144 patients with LVEF <30% (group 1) and 144 with LVEF >30% (group 2) had similar propensity scores and were included in the analyses. The primary study endpoint was significantlly higher in group 1 (33.3% vs. 9.4%, p = 0.002). There was a maintained improvement in secondary endpoints without significant differences among groups. Conclusion: FMR patients with LVEF <30% treated with MitraClip® had higher mortality and readmissions than patients with LVEF ≥30% treated with the same device. However, both groups improved the NYHA functional class and MR severity.
doi:10.3390/jcm9061792 pmid:32526978 fatcat:4ti745gaaff7ni54xqo2lzwnzi
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Isaac Pascual, Fernando Carrasco-Chinchilla, Tomas Benito-Gonzalez, Chi Hion Li, Pablo Avanzas, Luis Nombela-Franco, Manuel Pan, Ana Serrador Frutos, Xavier Freixa, Ramiro Trillo-Nouche, Rosa A. Hernández-Antolín, Leire Andraka Ikazuriaga, Ignacio Cruz-Gonzalez, Jose R. López-Mínguez, Jose L. Diez, Alberto Berenguer-Jofresa, Juan Sanchis, Valeriano Ruiz-Quevedo, Cristobal Urbano-Carrillo, Juan F. Oteo Dominguez, Maria R. Ortas-Nadal, Eduardo Molina Navarro, Xavier Carrillo, Juan H. Alonso-Briales, Felipe Fernández-Vázquez, Luis Asmarats Serra, Daniel Hernandez-Vaquero, Pilar Jimenez-Quevedo, Dolores Mesa, Tania Rodríguez-Gabella, Ander Regueiro, Amparo Martinez Monzonís, Luisa Salido Tahoces, Lara Ruiz Gomez, Blanca Trejo-Velasco, Victor M. Becerra-Muñoz, Carmen Garrote-Coloma, Estafanía Fernández Peregrina, Rebeca Lorca, Jose A. De Agustín, Miguel Romero, Ignacio J. Amat-Santos, Manel Sabaté, Ana B. Cid Alvarez, Jose M. Hernandez-Garcia, Javier Gualis, Dabit Arzamendi, Cesar Moris, Gabriela Tirado-Conte, Angel Sánchez-Recalde, Rodrigo Estevez-Loureiro. "Transcatheter Mitral Repair for Functional Mitral Regurgitation According to Left Ventricular Function: A Real-Life Propensity-Score Matched Study." Journal of Clinical Medicine 9.6 (2020) 1792