The hydrophobically-tagged MDM2-p53 interaction inhibitor Nutlin-3a-HT is more potent against tumor cells than Nutlin-3a

Florian Nietzold, Stefan Rubner, Thorsten Berg
2019 Chemical Communications  
We present the first application of hydrophobic tagging to a non-covalent inhibitor of protein-protein interactions. Nutlin-3a-HT, created by fusing the hydrophobic tag HyT13 to the MDM2-p53 interaction inhibitor Nutlin-3a, prevented...
doi:10.1039/c9cc07795b pmid:31720601 fatcat:ked6txjhizhmdjrk4jwglo5tsa