THE PRODUCTION OF AN ACUTE RESPIRATORY DISEASE IN MONKEYS BY INOCULATION WITH BACILLUS INFLUENZAE

FRANCIS G. BLAKE, RUSSELL L. CECIL
1920 Journal of the American Medical Association  
the cells surrounding the central vein. The line between the tumor cells and the liver cells was marked by a thin zone of scattered round cells with an occasional polymorphonuclear. Usually this line was cleancut and distinct. Occa¬ sionally tumor cells extended beyond it. The tumor cells were identical in appearance and arrangement to those in the tumor of the pleura. There was, however, very little con¬ nective tissue in the liver tumors. Metastatic Nodules in Left Pleura : The cells were
more » ... The cells were iden¬ tical to those described above. Those in advance filled the alveoli of the lung, and in many cases were limited to a given alveolus. Deeper in the tumor, however, the alveolar wall was represented only by a thin line of connective tissue. Right Suprarenal : The tumor was identical in every way to those just described. Its extending margins were clear and distinct. Metastasis into Brain: Here the cells were arranged in a more orderly manner. Many definite papillae were present. The margin invading the brain substance was somewhat more irregular, and frequently the cells extended deeply into the brain. However, the general characteristics of the tumor cells were the same as those of the pleura. The microscopic diagnosis was endothelioma of the right pleura with metastasis into the liver, left pleura, suprarenal, peritoneum and brain.
doi:10.1001/jama.1920.02620030026011 fatcat:x6i7tavw4ndr5gtg44rhnn2d6a