Objectives: The aim of this study was to assess the antibacterial effects of chlorhexidine gluconate, sodium fluoride, and sodium fluoride-xylitol combination mouthrinses on S. mutans biofilm in-vitro, and most significantly, we aimed to compare different restorative materials regarding the sensitivity of S. mutans biofilms formed on their surfaces to the antibacterial effects of the tested mouthrinses. Results: Chlorhexidine gluconate 0.12%, sodium fluoride 0.05%, and sodium fluoride 0.05%

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... itol 25% combination exhibited statistically significant antibacterial effects on S. mutans biofilm. The addition of xylitol 25% to sodium fluoride 0.05% mouthrinse was associated with higher antibacterial effects compared with sodium fluoride alone. S. mutans biofilms formed on GIC specimens exhibited the highest sensitivity to antibacterial treatments, whereas biofilms formed on stainless steel specimens showed the lowest sensitivity. Conclusion: S. mutans biofilms formed on different restorative materials exhibited different sensitivity levels to antimicrobial mouthrinses.