Antiasthmatic activity of 2-piperidone by selective animal models

Vani MAMILLAPALLI, Abdul Rahaman SHAIK, Prameela Rani AVULA
2020 Journal of Research in Pharmacy  
2-piperidone is a six membered heterocyclic compound existing naturally in piperaceae and portulaceae families. The synthetic derivatives of piperidone are promising bioactive molecules. They are antioxidant and antiinflammatory agents. Antihistaminic and anticholinergic studies are used as a part of antiasthmatic study. In the current study antihistaminic and anticholinergic studies were carried out using guinea pig bronchi and ilei in naturally isolated compound 2-piperidone from the plant
more » ... e from the plant Talinum portulacifolium. The results indicate that the compound (2 mg/kg 10.81 ± 1.29*** at p<0.001) showed profound antihistaminic activity significantly in histamine induced bronchospasm model than standard drug chlorpheniramine (2 mg/kg 8.77±0.43** at ** p<0.01). The compound can be further studied for antiasthmatic activity by various other ways to establish its mechanism of action as well as drug development studies to render it a novel antiasthmatic drug. (Dist.), A.P., India for their kind encouragement and support. Author contributions: Concept -Sk. A. R.; Design -M.V., Sk. A. R., A. P. R.; Supervision -A. P. R.; Resources -M.V.; Materials -M.V., Sk. A. R., A. P. R.; Data Collection and/or Processing -M.V., Sk. A. R.; Analysis and /or Interpretation -M.V., Sk. A. R.; Literature Search -M.V., Sk. A. R., A. P. R.; Writing -M.V.; Critical Reviews -M.V., Sk. A. R., A. P. R.
doi:10.35333/jrp.2020.155 fatcat:4ezezxjwtjco3l5jr5ipqnjb6u