Estimation of Prophylactic Efficacy of the Grippol® Vaccine for Large-Scale Immunization in Adult and Children's Organized Collectives in the Republic of Belarus

N. P. Shmeleva, V. P. Shimanovich, N. V. Sivets, T. P. Lapo, N. V. Gribkova
2017 Epidemiology and Vaccine Prevention  
estimation of anti-epidemic efficacy of a polymer-subunit vaccine Grippol® for large-scale immunization in adult work collectives and secondary schools in Vitebsk, Minsk and Grodno was conducted. Acute respiratory infection agents were detected by the means of RT-PCR in selected individuals. The overall number of participants was 12308 (5391 were children aged 6 - 17 and 6917 were 18 years or older). Influenza and ARI morbidity analysis demonstrates that Grippol® plus has a high anti-epidemic
more » ... igh anti-epidemic efficacy, reducing the influenza morbidity in the vaccinated cohort by 2.1 (adults) and 3.0 (children) times compared to that in unvaccinated persons. Efficacy and efficacy rate amounted to 50 3% and 2 2 in adults and 66 2% and 3 0 in children respectively A decrease in number of recurrent diseases complications in children was also demonstrated A dynamic morbidity analysis showed that in unvaccinated children there had been an evident increase in influenza and ARI among the unvaccinated children in late January - February 2016, while among the children who were vaccinated the morbidity rate was consistently low across all months of the influenza season.
doi:10.31631/2073-3046-2017-16-5-33-42 fatcat:iiae5ozfsfhw7etdylmgm5px2u