Analysis of Clinical Efficacy and Adverse Effects of β-Blocking Agents Used Clinically for Chronic Heart Failure

Risa Takayanagi, Kaori Fujito, Koji Kimura, Yasuhiko Yamada
2017 Biological and Pharmaceutical Bulletin  
Clinical efficacy and adverse effects of the β-blocking agents, carvedilol, bisoprolol, and metoprolol were analyzed theoretically, and then compared quantitatively, for the purpose of determining their proper use for chronic heart failure. Initially, we evaluated occupancy binding to the β 1 and β 2 receptors (Фss β 1 and Фss β 2 ) by these drugs. Thereafter, we examined the relationship between Фss β 1 values and left ventricular ejection fraction (LVEF) increase rate to determine efficacy.
more » ... termine efficacy. The result showed that the efficacy with carvedilol could be attained with a lower Фss β 1 value than the others. Therefore, we constructed a model under the assumption that β-blocking agents exert both indirect action of LVEF increase through the β 1 receptor and direct action on ryanodine receptor 2. Using the model, it was suggested that these drugs have no differences in regard to the efficacy, while it was clarified theoretically that only carvedilol produces an effect that directly involves ryanodine receptor 2 at clinical doses. We also investigated decreases in heart rate and forced expiratory volume in 1 s as adverse effects of β-blocking agents using a ternary complex model. It was indicated that carvedilol is less likely to induce a heart rate decrease. Meanwhile, it was also suggested that the risk of an asthmatic attack was higher for carvedilol at clinical doses. Our results are considered useful for selection of a proper β-blocking agent and its administration at a reasonable dose for successful heart failure therapy.
doi:10.1248/bpb.b16-00992 pmid:28566627 fatcat:v6rnhklkt5hjfbw6z4dl5k43u4