Brain transcriptome atlases: a computational perspective

Ahmed Mahfouz, Sjoerd M. H. Huisman, Boudewijn P. F. Lelieveldt, Marcel J. T. Reinders
2016 Brain Structure and Function  
The immense complexity of the mammalian brain is largely reflected in the underlying molecular signatures of its billions of cells. Brain transcriptome atlases provide valuable insights into gene expression patterns across different brain areas throughout the course of development. Such atlases allow researchers to probe the molecular mechanisms which define neuronal identities, neuroanatomy, and patterns of connectivity. Despite the immense effort put into generating such atlases, to answer
more » ... damental questions in neuroscience, an even greater effort is needed to develop methods to probe the resulting high-dimensional multivariate data. We provide a comprehensive overview of the various computational methods used to analyze brain transcriptome atlases.
doi:10.1007/s00429-016-1338-2 pmid:27909802 pmcid:PMC5406417 fatcat:zflsrogrsze53jro2ayrcdffs4