Restoration of Fracture Callus in Osteopetrotic (op/op) Mice by Injection of Macrophage Colony-stimulating Factor

TOSHITSUGU KAWATA, TADASHI FUJITA, SHINYA KOHNO, MASATO KAKU, CHIYOKO TOKIMASA, KAZUO TANNE
2000 Biomedical research  
Morphological studies on bone callus after fracture were carried out in normal and osteopetrotic mutant (op/op) mice, in which the tibiae diaphysis were subjected to subperiosteal osteotomy. The fracture callus passed through apparently normal stages in normal mice. Normal osteogenesis with woven bone and occasional cartilage islands were observed in the absence of osteoclasts on the bone surface in op/op mice when macrophage colonystimulating factor (M-CSF) was not injected. When M-CSF was
more » ... When M-CSF was injected into the op/op mice, the bone fracture callus passed through the healing stages that resembled to the stages in the normal mice. These results indicate that the fracture callus in the op/op mice may be secondary to abnormalities in bone resorption.
doi:10.2220/biomedres.21.17 fatcat:ymbxbtexrfcn5gg6m6hggubqea