Epidemiology of primary biliary cholangitis and its factors: An updated systematic review [post]

2019 unpublished
To understand the latest data on the prevalence and incidence rates for primary biliary cholangitis (PBC) and its factors, we systematically reviewed recent studies on epidemiology of PBC. Methods Case-finding and general population-based studies reporting prevalence and/or incidence rates for PBC were systematically identified by searching electronic databases combined with manual searching. Results A total of 37,452 PBC patients from 22 studies based on cases and 6 based on general population
more » ... general population were included, which covered over 112.62 million inhabitants and 107,490 individuals undergoing health check-ups. As for case-finding studies, global prevalence and incidence rates for PBC ranged from 2.6 to 58.2 per 100,000 inhabitants and 0.8 to 5.3 per 100,000 inhabitants/year during the past decade, in which the variable data are associated with gender, age, race and region. Of the individuals undergoing health check-ups, 1,034 were positive for type M2 antimitochondrial antibody (AMA-M2) and 150 were diagnosed as PBC, and prevalence rates of positive AMA-M2 and PBC ranged from 430.7 to 1,456.9 and 49.2 to 276.6 per 100,000 individuals. The prevalence ratios of male/female were 1:2.2 and 1:4.1 in individuals with positive AMA-M2 and in PBC patients. Conclusions Global prevalence and incidence rates for PBC vary widely, which were significantly affected by gender, age, race and region. Studies based on general population showed a much higher prevalence of PBC and AMA-M2, and the association of gender with AMA-M2 may be far less than that with PBC in real world. Backgrounds Primary biliary cholangitis (PBC) is one of cholestatic liver diseases, which is induced by immunemediated damage of biliary epithelial cells and characterized by destruction of small intrahepatic bile ducts with risk for progression to biliary fibrosis, even ultimately to cirrhosis, and hepatocellular cancer. The pathogenesis of PBC is still unclear. Most patients present asymptomatically, and clinical symptoms are frequently fatigue, pruritis and arthralgia in some of PBC patients. A diagnosis of PBC can be made based on elevated alkaline phosphatase (ALP) and positive antimitochondrial antibody (AMA) at a titer ≥ 1:40. Histology is usually not necessary for diagnosis unless specific antibodies are
doi:10.21203/rs.2.14641/v1 fatcat:uijjvltsgvfh3o5azmzfvjnc6i