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Inhibitory effect of Aristolochia fruit on Cytochrome P450 isozymes in vitro and in vivo
2015
Pakistan Journal of Pharmaceutical Sciences
The mature fruits of Aristolochia debilis, known in China by the name, "Madouling" has been popularly prescribed in Asia, particularly in China, to treat a range of conditions including gynaecological problems, arthritis and wound healing. This study was aimed to evaluate the potential effect of Madouling on the cytochrome P450 (CYP) isozymes in vitro in microsomal fractions and in vivo in rats. The influence of Madouling on CYPs activity was first explored by an in vitro method of estimating
pmid:26004704
fatcat:h3pwzmciazdddfq5psmp4xqqgm