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Fasting Intact Proinsulin Is a Highly Specific Predictor of Insulin Resistance in Type 2 Diabetes
OBJECTIVE -In later stages of type 2 diabetes, proinsulin and proinsulin-like molecules are secreted in increasing amounts with insulin. A recently introduced chemiluminescence assay is able to detect the uncleaved "intact" proinsulin and differentiate it from proinsulin-like molecules. This investigation explored the predictive value of intact proinsulin as an insulin resistance marker. RESEARCH DESIGN AND METHODS -In total, 48 patients with type 2 diabetes (20 women and 28 men, aged 60 Ϯ 9doi:10.2337/diacare.27.3.682 pmid:14988285 fatcat:yrvna3opsrhgxmw3x47lfpgjmy