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Can thymic epithelial cells be infected by human T-lymphotropic virus type 1?
2011
Memórias do Instituto Oswaldo Cruz
The human T-lymphotropic virus type-1 (HTLV-1) is the cause of adult T cell leukaemias/lymphoma. Because thymic epithelial cells (TEC) express recently defined receptors for the virus, it seemed conceivable that these cells might be a target for HTLV-1 infection. We developed an in vitro co-culture system comprising HTLV-1 + -infected T cells and human TECs. Infected T cells did adhere to TECs and, after 24 h, the viral proteins gp46 and p19 were observed in TECs. After incubating TECs with
doi:10.1590/s0074-02762011000600018
pmid:22012233
fatcat:t3nmagpebre5jiaa5jk7bt3cfq