389 Chemotherapy during pregnancy and neonatal outcome: a retrospective analysis on 47 patients

Eugenia DI Loreto, Alessandra Familiari, Veronica Accurti, Tiziana Boggini, Carlotta Castellani, Gianpiero Polverino, Julia Bewart, Monica Fumagalli, Fedro Alessandro Peccatori, Giovanna Scarfone
2020 Fertility pregnancy   unpublished
secondary surgery (further FSS in 34). At univariate analysis, significant predictors of relapse were: size of largest extraovarian lesion, peritoneal cancer index, completeness of cytoreduction, type of implants. After multivariable analysis, the size of extra-ovarian lesions and the presence of invasive implants resulted as the only independent predictors of recurrence (Tab. 1). Median DFS and DSS were respectively 96 months (95% CI, 17.5-174.4) and 290.4 months (95% CI, 280.8-299.9) (figure
more » ... ). Thirty-one patients attempted to conceive: 23 (74.2%) achieved at least one pregnancy and 20 (64.5%) gave birth to a healthy child. At the end of the observation period, 96 patients (95%) showed no evidence of disease, 2 (2%) were alive with disease, and 3 patients (3%) died from BOT. Conclusions Despite the recurrence high rate, the survivals and pregnancy outcomes indicate that FSS could be considered in advanced BOTs. Among predictors of recurrence, oophorectomy (vs. cystectomy) has resulted not significant as in earlystage BOTs likely due to the advanced-stage setting. Size of extra-ovarian lesions and presence of invasive implants were the only significant predictors. Completeness of cytoreduction was lacking significance likely because of low number of patients with residual disease. Disclosures All authors declare no financial support or relationships that may pose conflict of interest. Data are given as mean ± SD or n(%). Abstract 389 Table 2 Results of the linear regression analysis of factors associated with neonatal outcomes BW=Birthweight; Hb=Haemoglobin, WBC=White Blood Cells
doi:10.1136/ijgc-2020-esgo.85 fatcat:b7jn7i5uzjdmpdp2iqu3ugfywq