T- cell prolymphocytic leukemia - A rare case

Sharmila Ghosh, SureshH Advani
2005 Indian Journal of Cancer  
T-cell Prolymhocytic leukemia (T-PLL) is a rare mature post-thymic T-cell malignancy that is usually reported in the elderly and follows an aggressive course. A 68 year old male presented with a history of weakness and weight loss of two months duration. Clinical examination revealed pallor, enlarged cervical and axillary lymph nodes and splenomegaly. He also had a maculo-papular skin rash. There was marked leucocytosis, anemia and thrombocytopenia (WBC 445 x10 3 /ml, Hb 8.5gm/dl, Platelet
more » ... m/dl, Platelet 25x10 3 /µl) with 60% prolymphocytes in the peripheral blood. Bone marrow was hypercellular with an excess of prolymphocytes. Flow cytometric analysis of the bone marrow showed positivity for CD2, CD3, CD4, CD5 and CD7. T-PLL is a rare T cell disorder with characteristic clinical and laboratory features.Currently, no optimal treatment exists although there has been some success with 2'-deoxycoformycin or Campath-1H
doi:10.4103/0019-509x.16702 fatcat:4awxzc3snzbpnlrubhawxrkwse