452Pseudo-Outbreak of Fulminant Toxoplasmosis in Hematopoietic Stem Cell Transplant [HSCT] Recipients

Flonza Isa, Mini Kamboj, Koen Van Besien, Audrey N. Schuetz, Steven Salvatore, Genovefa A. Papanicolaou, Rosemary Soave
2014 Open Forum Infectious Diseases  
We report a cluster of six cases of fulminant toxoplasmosis in cord and/or ex-vivo T-cell depleted stem cell allograft recipients in two neighboring institutions in New York City. A detailed epidemiologic investigation did not reveal any common link between the six cases. While the exact etiology for the increased incidence of toxoplasmosis could not be elucidated, endogenous reactivation is the most likely explanation for the observed cluster of cases. All of our patients were at high risk for
more » ... re at high risk for toxoplasmosis reactivation based on previously reported risk factors, including: recipient positive toxoplasma IgG pre-transplant, T-cell depletion, myeloablative conditioning, negative donor serology, cord blood transplant, and/or heavy immunosuppression post transplant. 4-5
doi:10.1093/ofid/ofu052.318 fatcat:wdkg37qguvc2hpj4xyqeqt2mbe