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We report a cluster of six cases of fulminant toxoplasmosis in cord and/or ex-vivo T-cell depleted stem cell allograft recipients in two neighboring institutions in New York City. A detailed epidemiologic investigation did not reveal any common link between the six cases. While the exact etiology for the increased incidence of toxoplasmosis could not be elucidated, endogenous reactivation is the most likely explanation for the observed cluster of cases. All of our patients were at high risk fordoi:10.1093/ofid/ofu052.318 fatcat:wdkg37qguvc2hpj4xyqeqt2mbe