The relationship between inflammation and the coagulation system

Goda Choi, Marcus J Schultz, Marcel Levi, Tom van der Poll
2006 Swiss Medical Weekly  
Inflammation and coagulation play pivotal roles in host defence. As phylogenetically old responses, there is extensive cross-talk between inflammation and coagulation in enabling an adequate immune response against potentially injurious stimuli. Immune cells are important in the initiation of coagulation pathways, while various inflammatory mediators are capable of altering haemostasis. Vice versa, coagulation proteases have significant immunomodulatory effects. Understanding the mechanisms
more » ... the mechanisms involved in the crosstalk between inflammation and coagulation may yield new therapeutic strategies for human diseases.
pmid:16633958 fatcat:fmswwx52u5dbhp6grcorcim4lu